Five Things You Need to Know about Colorectal Cancer Prevention

March 8, 2016 Brigham and Women's Hospital

Jeffrey Meyerhardt

Dr. Jeffrey Meyerhardt

While one of the most common cancers in both men and women, colorectal cancer remains a very preventable disease, says Jeffrey Meyerhardt, MD, MPH, Clinical Director of the Gastrointestinal Cancer Center at Dana-Farber/Brigham and Women’s Cancer Center (DF/BWCC).

“Most of these cancers develop over a period of years,” says Dr. Meyerhardt. “While not preventable in everyone, the earlier you detect the disease, the more curable it is.”

Below are some tips from Dr. Meyerhardt on ways to reduce your risk.

Live a healthy lifestyle.

“There are various dietary factors that play a role in colorectal cancer,” explains Dr. Meyerhardt. “The one that’s the most consistently shown in studies is red and processed meat.” To lower your risk, Dr. Meyerhardt recommends eating fewer than two servings of red or processed meat per week. This includes foods such as steak, hamburgers, and hot dogs.

Other lifestyle factors that increase the risk of colorectal cancer are obesity and physical inactivity, as these increase insulin levels that may help drive cancer cell growth. Ideally, you should exercise at least 150 minutes per week, but any amount is better than being inactive, Dr. Meyerhardt says. Following this guideline can help you maintain good health and decrease your risk of colorectal cancer and many other diseases. Multiple studies conducted at DF/BWCC have shown consistent associations between increased physical activity and lower risk of recurrence in colorectal cancer survivors.

 Eat enough nuts and drink coffee.

Nuts – of any kind – have been shown to have a positive effect on decreasing risk for pancreatic cancer and other diseases, including colorectal cancer. Nuts have been found to reduce rates of insulin resistance, which can increase the risk of colorectal cancer. Eating one ounce of nuts five or more times per week has been found to reduce death from all causes by 20 percent.

Coffee consumption also has been linked to a lower colorectal cancer risk, including for recurrent disease in survivors, as it seems to be associated with insulin-resistance pathways, says Dr. Meyerhardt.

Consider taking aspirin and vitamin D supplements.

While many people take aspirin for cardiovascular disease, the drug also seems to have a risk-reducing correlation with colorectal cancer. This is an area of ongoing research, Dr. Meyerhardt cautions, and there are risks to aspirin intake, notably the possibility of ulcers and upper gastrointestinal bleeding, so be sure to weigh the risks and benefits with your physician.

Vitamin D helps the body regulate calcium levels and maintain healthy bones. The risk-reduction benefits of this supplement for cancer, heart disease, and stroke are currently being evaluated through the VITAL Study at Brigham and Women’s Hospital. Like aspirin, Dr. Meyerhardt recommends speaking with your physician before taking any supplement.

Follow screening recommendations.

“Colorectal cancer is one of the cancers where there has been the most consistent evidence suggesting the benefits of screening,” says Dr. Meyerhardt, noting there are a variety of tests, including colonoscopy, sigmoidoscopy, and fecal occult blood testing, to screen for colorectal cancer and polyps.

No matter the method, screening should begin for the general population at age 50. Those with risk factors, such as a family history, should discuss with their doctor when to begin screening. Fecal occult blood tests should be done yearly, while colonoscopies are every eight to ten years and sigmoidoscopies every five years.

Know your family history.

One of the major risk factors for colorectal cancer is heredity. This includes a family history of colorectal cancer or polyps, or having a genetic syndrome such as Lynch syndrome, which increases colorectal cancer risk, as well as the risk of developing endometrial or ovarian cancer. Individuals with a genetic syndrome tend to develop colorectal cancer at a younger than average age. These people account for five percent of all colorectal cancer patients, while those with a family history of the disease make up 15 percent of all cases, says Dr. Meyerhardt.

Pay attention to your family history and speak with your doctor about screening if you think you are at an elevated risk.

This post originally appeared on Insight, the blog of Dana-Farber Cancer Institute.

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