Brigham and Women's Hospital Articles

Oncology Advances October 2014

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Page 2 Dana-Farber/Brigham and Women's Cancer Center Experts Present Groundbreaking Findings at ASCO At the 50th Annual Meeting of the American Society of Clinical Oncology, more than 75 investigators from Dana-Farber/Brigham and Women's Cancer Center presented new research results, including groundbreaking findings that may lead to changes in the standard of care for appropriate patient populations. Page 4 New Strategies Combat Resistance to EGFR Inhibitors in Lung Cancer Patients Oncologists in the Lowe Center for Thoracic Oncology at Dana- Farber/Brigham and Women's Cancer Center are leading new approaches for non-small cell lung cancer patients who develop resistance to current epidermal growth factor receptor inhibitors. Medical oncologists in the Center lead an average of 15 clinical tri- als at a time and were among the first to discover EGFR mutations in non-small cell lung cancer and demonstrate clinical response to gefitinib and erlotinib in patients with EGFR mutations. Page 5 T-DM1 Trials Lead to Expanded Options for Patients with HER2-positive Breast Cancer Medical oncologists in the Susan F. Smith Center for Women's Cancers at Dana-Farber/Brigham and Women's Cancer Center are conducting trials of ado-trastuzumab emtansine (T-DM1) to provide new options for patients with early-stage disease and enhance treatment response in patients with advanced HER2- positive breast cancer. Page 6 Center for Immuno-Oncology Studies Span Many Cancer Types Facilitating collaboration in immunotherapy research encompassing a broad range of solid tumors and hematologic malignancies, specialists in the Center for Immuno-Oncology at Dana-Farber/Brigham and Women's Cancer Center are currently offering 12 trials and have six additional studies in development. Now Available: Next Day Access for New Patients in Boston September 2014 ONCOLOGY Advances

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