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Oncology Advances October 2015

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Page 2 PD-1 Inhibitor Trials Target Gastrointestinal Cancers, Span Many Cancer Types in Combination Studies Immunotherapy trials at Dana-Farber/Brigham and Women's Cancer Center using PD-1 inhibitors have expanded to include studies for several gastrointestinal cancers and combination studies spanning a wide range of cancers. Page 4 New Study Finds Many Patients Choose Mastectomy, Despite Eligibility for Breast Conserving Therapy Mehra Golshan, MD, Dr. Abdul Mohsen and Sultana Al-Tuwaijri Distinguished Chair in Surgical Oncology at Brigham and Women's Hospital and Medical Director of International Oncology Programs at Dana-Farber/Brigham and Women's Cancer Center, presented findings evaluating the impact of neoadjuvant chemotherapy in Stage II-III triple negative breast cancer on eligibility for breast conserving surgery. Page 5 New Clinic Studies Innovative Approaches to Prevent the Progression of Blood Cancer in Patients with Precursor Conditions The new Blood Cancer Prevention of Progression Clinic is designed to enhance the understanding of the progression and clonal evolution of blood cancers in order to provide targeted approaches to prevent the development of blood cancers in patients with precursor conditions. Page 6 Thyroid Cancer Center Focuses on Targeted Therapy, Tailored Approaches to Evaluation and Treatment The multidisciplinary team in the new Thyroid Cancer Center is employing novel approaches to the evaluation, diagnosis, treatment, and management of all forms of thyroid cancer, as well as nodular disease. Page 7 Now Available: Next Day Access for New Patients in Boston October 2015 ONCOLOGY

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