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Oncology-Advances-January-2016

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Page 2 Dana-Farber/Brigham and Women's Cancer Center Research on Monoclonal Antibodies Shows Promise in Multiple Myeloma New monoclonal antibodies for multiple myeloma co-developed by hemato-oncologists at the Jerome Lipper Multiple Myeloma Center at Dana-Farber/Brigham and Women's Cancer Center could become the next blockbusters in this malignancy. According to results from two recently published clinical trials, the new drugs have impressive efficacy in patients with relapsed and relapsed/refractory disease. Page 4 Radiation Therapy for Prostate Cancer, Innovative BWH Technique Preserves Rectal Tissue Brigham and Women's Hospital was the first hospital in Massachusetts and one of the first in the United States to use an innovative technique for preserving rectal tissue while increasing the effectiveness of radiation therapy for treating adenocarcinoma of the prostate. Page 6 Early-phase Trials at Dana-Farber/Brigham and Women's Cancer Center Explore Novel Combinations for Ovarian Cancer Building on recent discoveries at Dana-Farber/Brigham and Women's Cancer Center using a variety of inhibitor combinations, researchers in the Susan F. Smith Center for Women's Cancers are leading new early-phase trials for patients with ovarian cancer. Page 7 Researchers Investigate Ductal Cell Carcinoma In-Situ, Propose Less Aggressive Strategies for Low-risk Lesions Breast cancer specialists at Dana-Farber/Brigham and Women's Cancer Center are pioneering efforts to identify subsets of patients with ductal cell carcinoma in-situ (DCIS) who might appropriately avoid aggressive treatment. Winter 2015 ONCOLOGY

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