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Oncology Advances April 2016

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Page 2 Preventing Drug Resistance in Advanced Renal Cell Carcinomas Genitourinary cancer researchers at Dana-Farber/Brigham and Women's Cancer Center are investigating novel therapeutics and drug combinations that may circumvent the development of resistance to targeted therapies in patients with metastatic or recurrent renal cell carcinoma. Page 5 The Prostate in 3-D: A Model for Preserving Continence and Sexual Function Adam S. Kibel, MD, Disease Center Leader, Urology at Dana-Farber/Brigham and Women's Cancer Center, and colleagues are leading research to determine whether 3-D modeling could improve management of patients with prostate cancer. Page 4 Team Develops Genomic Test to Pinpoint Brain Tumor Diagnoses and Deliver Valuable Information for Prognosis and Clinical Research Cytogeneticists and pathologists in the Department of Pathology and Center for Neuro-Oncology at Dana-Farber/Brigham and Women's Cancer Center have developed a whole genome array comparative genomic hybridization test (array CGH) to accurately diagnose various types of brain tumors. Page 6 Novel Neoadjuvant Trial Demonstrates Biomarker Response in Patients with Malignant Pleural Mesothelioma Experts from Dana-Farber/Brigham and Women's Cancer Center recently presented preliminary results of an ongoing Phase II investigator-initiated neoadjuvant study of defactinib in patients with surgically-resectable malignant pleural mesothelioma and have modified the trial for subsequently enrolled patients. dfbwcc.org Winter 2016 ONCOLOGY Advances

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