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Oncology Advances January 2017

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Page 2 New Bcl-2 Inhibitor Studies Expand Options for Patients with Hematologic Malignancies, Build on Decades of Research Hematologic oncologists in the Center for Hematologic Oncol- ogy at Dana-Farber/Brigham and Women's Cancer Center are leading studies of venetoclax (ABT-199), a first-in-class Bcl-2 in- hibitor approved for patients with relapsed chronic lymphocytic leukemia with 17p deletion. Page 5 Liquid Biopsy for Lung Cancer Delivers Faster Diagnosis and Targeted Treatments Developed by experts at Dana-Farber/Brigham and Women's Cancer Center, a new blood test using rapid plasma genotyping to detect epidermal growth factor receptor (EGFR) and KRAS mutations is enabling much more rapid diagnosis and com- mencement of targeted therapies for patients with non-small cell lung cancer. Page 4 Team Investigates Key Factors in Patient Decision-making Amid Growing Rates and Lack of Survival Benefit in Contralateral Prophylactic Mastectomy While rates of contralateral prophylactic mastectomy (CPM) more than tripled between 2002 and 2012, researchers at Dana- Farber/ Brigham and Women's Cancer Center (DF/BWCC) have found no survival benefit among patients choosing CPM over breast conservation. DF/BWCC researchers are conducting on- going research to examine the primary factors that contribute to patients' decisions to undergo CPM. Page 6 Enhanced Recovery After Surgery Protocol Demonstrates Reduction in Complications and Length of Stay Surgical teams at Dana-Farber/Brigham and Women's Cancer Center are expanding their use of the Enhanced Recovery After Surgery (ERAS ® ) protocol based on the results seen among hundreds of patients. dfbwcc.org October 2016 ONCOLOGY Advances

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